Home Categories Biochemical Engineering L-Asparagine
A7671258

L-Asparagine , 10mMinWater , 70-47-3

Synonym(s):
(S)-2-Aminosuccinic acid 4-amide;L-Aspartic acid 4-amide

CAS NO.:70-47-3

Empirical Formula: C4H8N2O3

Molecular Weight: 132.12

MDL number: MFCD00064401

EINECS: 200-735-9

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 235 °C (dec.) (lit.)
Boiling point: 244.01°C (rough estimate)
alpha  34.5 º (c=10, 2N HCl)
Density  1,543g/cm
refractive index  1.4880 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  Practically insoluble in methanol, ethanol, ether, benzene. Soluble in acids and alkalies.
pka 2.17(at 20℃)
form  Powder
color  White
Odor sltly sweet taste
PH 5.41
optical activity -5.625 (H2O)+28.625 (1 mol dm-3 HCl)
Water Solubility  H2O: 20 g/L (20 oC) , clear, colorless
Sensitive  Hygroscopic
Merck  14,837
BRN  1723527
Stability: Stable, but may be moisture-sensitive. Incompatible with strong oxidizing agents.
LogP -3.820

Description and Uses

Asparagine (abbreviated as Asn or N) is one of the 20 most common natural amino acids on Earth. It has carboxamide as the sidechain's functional group. It is not an essential amino acid. Its codons are AAU and AAC.
The amino acid L-asparagine is a structural analog of L-aspartic acid, where the side chain of the carboxylic acid moiety is amidated, to give a terminal amine group. This renders L-asparagine neutral at physiological pH. The amide group of asparagine is derived from glutamate, in the reaction of aspartate and glutamine in the presence of ATP to yield asparagine and glutamate. In vivo, asparagine is hydrolyzed to aspartate and NH4+ by asparaginase. Asparagine is also an important amino acid in glycopeptide bonds, via N-glycosyl linkages to the sugar rings.

L-asparagine has been used:
to identify and quantify free amino acids released upon oxidation of proteins and peptides by hydroxyl radicals.
to study the effects of amino acids in promoting food consumption in Drosophila melanogaster.
to study non-enzymatic gluconeogenesis.
L-Asparagine is used in cell culture media and is a component of MEM non-essential amino acids solution.
L-Asparagine has been shown to enhance ornithine decarboxylase activity in cultured human colon adenocarcinoma Caco-2 cells and in cultured IEC-6 intestinal epithelial cells. Spore germination in Bacillus subtilis has been increased in the presence of L-asparagine.
An isoxazoline RGD mimic platelet GPIIb/IIIa antagonist has been prepared by chiral synthesis with L-asparagine as a starting material. L-Asparagine has been utilized in the synthesis of 4-azalysine building blocks for application to combinatorial chemistry.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  24/25-36-26
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
3-10
TSCA  Y
HazardClass  IRRITANT
HS Code  29241900

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