Home Categories Organic Chemistry Trimethyl orthoformate
A7667412

Trimethyl orthoformate , 99.8%, no water grade , 149-73-5

Synonym(s):
Methyl orthoformate, Orthoformic acid trimethyl ester;TMOF;Trimethoxymethane;Trimethyl orthoformate

CAS NO.:149-73-5

Empirical Formula: C4H10O3

Molecular Weight: 106.12

MDL number: MFCD00008483

EINECS: 205-745-7

Update time: 2022-07-08

PRODUCT Properties

Melting point: -53 °C
Boiling point: 101-102 °C(lit.)
Density  0.97 g/mL at 25 °C(lit.)
vapor density  3.67 (vs air)
vapor pressure  23.5 mm Hg ( 20 °C)
refractive index  n20/D 1.379(lit.)
Flash point: 60 °F
storage temp.  Store below +30°C.
solubility  Miscible with ether, alcohol and benzene.
form  Liquid
color  Clear colorless
explosive limit 1.4-44.6%(V)
Water Solubility  10 g/L (hydrolysis)
Sensitive  Moisture Sensitive
Merck  14,6884
BRN  969215
InChIKey PYOKUURKVVELLB-UHFFFAOYSA-N
LogP -0.03-0.09 at 20℃

Description and Uses

Trimethyl orthoformate is an effective solvent for thallium(III) nitrate-mediated oxidations. It undergoes acid catalyzed reaction with 6-(N-D-ribitylanilino) uracils to form 8-demethyl-8-hydroxy-5-deazariboflavins.

Trimethyl Orthoformate is the most simple orthoester. Used in organic synthesis as a reagent for introducing a protecting group for aldehydes and in the creation of methoxymethylene groups and heterocyclic ring systems.

Safety

Symbol(GHS) 
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319
Precautionary statements  P210-P233-P240-P241-P242-P305+P351+P338
Hazard Codes  F,Xi
Risk Statements  11-36
Safety Statements  9-16-26-29
RIDADR  UN 3272 3/PG 2
WGK Germany  1
RTECS  RM6650000
Autoignition Temperature 255 °C
TSCA  Yes
HazardClass  3
PackingGroup  II
HS Code  29159080
Toxicity LD50 orally in Rabbit: 3130 mg/kg

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