Triethylenetetramine , StandardforGC , 112-24-3
Synonym(s):
DEH 24;EPH 925;N,N′-Bis(2-aminoethyl)-1,2-ethanediamine;TETA;Triethylenetetramine
CAS NO.：112-24-3
Empirical Formula: C6H18N4
Molecular Weight: 146.23
MDL number: MFCD00008169
EINECS: 203-950-6
PRODUCT Properties
| Melting point: | 12 °C(lit.) |
| Boiling point: | 266-267 °C(lit.) |
| Density | 0.982 g/mL at 25 °C(lit.) |
| vapor density | ~5 (vs air) |
| vapor pressure | <0.01 mm Hg ( 20 °C) |
| refractive index | n |
| Flash point: | 290 °F |
| storage temp. | Store below +30°C. |
| solubility | alcohol: soluble |
| pka | pK1:3.32(+4);pK2:6.67(+3);pK3:9.20(+2);pK4:9.92(+1) (20°C) |
| form | Slightly viscous yellow
liquid; commercially available form is 95–98%
pure, and impurities include linear, branched,
and cyclic isomers. |
| color | Yellowish liquid or oil |
| PH | 10-11 (10g/l, H2O, 20℃) |
| explosive limit | 0.7-7.2%(V) |
| Water Solubility | SOLUBLE |
| FreezingPoint | 12℃ |
| Sensitive | Moisture Sensitive |
| Merck | 14,9663 |
| BRN | 605448 |
| Exposure limits | ACGIH: TWA 1 ppm (Skin) NIOSH: TWA 1 ppm(4 mg/m3) |
| Stability: | Incompatible with strong oxidizing agents, strong acids. |
| LogP | -2.65 at 20℃ |
| CAS DataBase Reference | 112-24-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Triethylenetetramine(112-24-3) |
| EPA Substance Registry System | Triethylenetetramine (112-24-3) |
Description and Uses
Triethylenetetramine (TETA and trien) also known as trientine (INN) when used medically, is an organic compound with the formula [CH2NHCH2CH2NH2]2. The pure freebase is a colorless oily liquid, but, like many amines, older samples assume a yellowish color due to impurities resulting from air- oxidation. It is soluble in polar solvents. The branched isomer tris(2-aminoethyl)amine and piperazine derivatives may also be present in commercial samples of Triethylenetetramine. The hydrochloride salts are used medically as a treatment for copper toxicity.
Triethylenetetramine is used as an amine hardener in epoxy resin of the bisphenol A type.It is used in synthesis of detergents, softeners, and dyestuffs; manufacture of pharmaceuticals; vulcanization accelerator of rubber; thermo setting resin; epoxy curing agent; lubricating-oil additive; analytical reagent for Cu, Ni; chelating agent; treatment of Wilson's disease.
Safety
| Symbol(GHS) |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H312-H314-H317-H412 |
| Precautionary statements | P261-P272-P273-P280-P303+P361+P353-P305+P351+P338 |
| Hazard Codes | C |
| Risk Statements | 21-34-43-52/53 |
| Safety Statements | 26-36/37/39-45-61 |
| RIDADR | UN 2259 8/PG 2 |
| WGK Germany | 2 |
| RTECS | YE6650000 |
| Autoignition Temperature | 335 °C |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29212900 |
| Hazardous Substances Data | 112-24-3(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 2.5 g/kg (Spitz) |
