Home Categories Organic Chemistry Trifluoroacetic acid(TFA)
A7659712

Trifluoroacetic acid(TFA) , AR,99.0% , 76-05-1

Synonym(s):
TFA;TFA in H2O/ACN;TFA solution;Trifluoroacetic acid solution;Trifluoroacetic acid ZerO2

CAS NO.:76-05-1

Empirical Formula: C2HF3O2

Molecular Weight: 114.02

MDL number: MFCD00004169

EINECS: 200-929-3

Update time: 2022-07-08

PRODUCT Properties

Melting point: -15.4 °C (lit.)
Boiling point: 72.4 °C (lit.)
Density  1.489 g/mL at 20 °C (lit.)
vapor density  3.9 (vs air)
vapor pressure  97.5 mm Hg ( 20 °C)
refractive index  n20/D 1.3(lit.)
Flash point: None
storage temp.  Store at +15°C to +25°C.
solubility  Miscible with ether, acetone, ethanol, benzene, hexane, and CCl<sub>4</sub>
pka -0.3(at 25℃)
form  Liquid
color  Colorless
Specific Gravity 1.480
Odor Sharp, pungent odor
PH Range 1
PH 1 (10g/l, H2O)
Water Solubility  miscible
Sensitive  Hygroscopic
λmax λ: 260 nm Amax: 0.9
λ: 270 nm Amax: 0.10
λ: 280 nm Amax: 0.05
λ: 290 nm Amax: 0.04
λ: 300 nm Amax: 0.03
λ: 320 nm Amax: 0.025
Merck  14,9681
BRN  742035
Dielectric constant 23.7(20℃)
Stability: Stable. Incompatible with combustible material, strong bases, water, strong oxidizing agents. Non-combustible. Hygroscopic. May react violently with bases.
InChIKey DTQVDTLACAAQTR-UHFFFAOYSA-N

Description and Uses

Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. The combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid can use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry. It is used as a catalyst in esterification reaction and condensation reaction and a protective agent for hydroxyl and amino.

Safety

Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H314-H332-H412
Precautionary statements  P261-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  C,T,Xi
Risk Statements  20-35-52/53-34
Safety Statements  9-26-27-28-45-61-28A-36/37/39
RIDADR  UN 2699 8/PG 1
WGK Germany  2
RTECS  AJ9625000
3
Hazard Note  Toxic/Corrosive
TSCA  T
HazardClass  8
PackingGroup  I
HS Code  29159080
Toxicity LD50 i.v. in mice: 1200 mg/kg (Airaksinen, Tammisto)

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