Home Categories Organic Chemistry Tetrahydrofuran
A7658612

Tetrahydrofuran , Waterless grade, ≥99.9%, no stabilizer , 109-99-9

Synonym(s):
THF;Tetrahydrofuran;Oxolane;Butylene oxide;PTHF

CAS NO.:109-99-9

Empirical Formula: C4H8O

Molecular Weight: 72.11

MDL number: MFCD00005356

EINECS: 203-726-8

Update time: 2022-07-08

PRODUCT Properties

Melting point: -108°C
Boiling point: 66 °C
Density  0.887 g/mL at 20 °C
vapor density  2.5 (vs air)
vapor pressure  <0.01 mm Hg ( 25 °C)
refractive index  n20/D 1.465
Flash point: >230 °F
storage temp.  Store at +5°C to +30°C.
solubility  water: soluble
form  Liquid
color  <10(APHA)
Specific Gravity 0.89
PH Range 7
Odor Ethereal, detectable at 2 to 50 ppm
Relative polarity 0.207
PH 7-8 (200g/l, H2O, 20℃)
explosive limit 1.5-12.4%(V)
Water Solubility  miscible
FreezingPoint  -108℃
Sensitive  Air Sensitive & Hygroscopic
λmax λ: 245 nm Amax: ≤0.26
λ: 275 nm Amax: ≤0.046
λ: 315 μm Amax: ≤0.0044
Merck  14,9211
BRN  102391
Henry's Law Constant 1.54 (static headspace-GC, Welke et al., 1998)
Exposure limits TLV-TWA 200 ppm (590 mg/m3) (ACGIH, MSHA, and OSHA); STEL 250 ppm (ACGIH); IDLH 20,000 ppm (NIOSH).
Dielectric constant 11.6(-70℃)
Stability: Stable. Incompatible with halogens, strong oxidizing agents, strong reducing agents, strong bases, oxygen. May generate explosive peroxides in storage if in contact with air. Highly flammable. Store at room temperature under nitrogen. Hazardous polymerisation may occur. Light sensitive. May contain 2,6-di-tertbutyl-4-methylphenol (BHT) as a s
InChIKey WYURNTSHIVDZCO-UHFFFAOYSA-N
LogP 0.45 at 25℃

Description and Uses

Tetrahydrofuran (THF) is a colorless, volatile liquid with an ethereal or acetonelike smell and is miscible in water and most organic solvents.It is highly flammable and may thermally decompose to carbon monoxide and carbon dioxide. Prolonged storage in contact with air and in the absence of an antioxidant may cause THF to decompose into explosive peroxides.

Tetrahydrofuran is used in the manufacture of polymers as well as agricultural, pharmaceutical, and commodity chemicals. Manufacturing activities commonly occur in closed systems or under engineering controls that limit worker exposure and release to the environment. THF is also used as a solvent (e.g., pipe fitting) that may result in more significant exposures when used in confined spaces without sufficient ventilation. Although THF is naturally present in coffee aroma, floured chickpeas, and cooked chicken, natural exposures are not anticipated to pose a significant hazard.

Tetrahydrofuran is used as a solvent forresins, vinyls, and high polymers; as a Grignardreaction medium for organometallic,and metal hydride reactions; and in the synthesisof succinic acid and butyrolactone.

Safety

Symbol(GHS) 
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H225-H302-H319-H335-H336-H351
Precautionary statements  P201-P202-P210-P301+P312-P305+P351+P338-P308+P313
Hazard Codes  Xi,F,Xn
Risk Statements  36/37/38-36/37-19-11-40
Safety Statements  26-36-33-29-16-46-37-13
OEB A
OEL TWA: 200 ppm (590 mg/m3), STEL: 250 ppm (735 mg/m3)
RIDADR  UN 2924 3/PG 2
WGK Germany  1
RTECS  MD0916000
3-10-23
Autoignition Temperature 610 °F
TSCA  Yes
HazardClass  3
PackingGroup  II
HS Code  29321100
Toxicity LD50 oral (rat) 2880 mg/kg
LC50 inhal (rat) 21,000 ppm (3 h)
PEL (OSHA) 200 ppm (590 mg/m3)
TLV-TWA (ACGIH) 200 ppm (590 mg/m3)
STEL (ACGIH) 250 ppm (737 mg/m3)
IDLA 2,000 ppm [10% LEL]

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