Mecamylaminehydrochloride , 10mMinDMSO , 826-39-1

Synonym(s):
2-(Methylamino)isocamphane hydrochloride;Inversine;N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride

CAS NO.：826-39-1

Empirical Formula: C11H22ClN

Molecular Weight: 203.75

MDL number: MFCD00151462

EINECS: 212-555-8

PRODUCT Properties

• Melting point: >240°C (dec.)
• storage temp.: 2-8°C
• solubility: ethanol: 122 mg/mL
• pka: pKa 11.2(H2O,t undefined,I=0.1) (Uncertain)
• form: Solid
• color: White to off-white
• Stability: Hygroscopic
• CAS DataBase Reference: 826-39-1(CAS DataBase Reference)
• EPA Substance Registry System: Bicyclo[2.2.1]heptan-2-amine, N,2,3,3-tetramethyl-, hydrochloride (1:1) (826-39-1)

Description and Uses

Mecamylamine hydrochloride is a non-competitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM), previously used to treat hypertension.Displays antidepressant-like effects in mice.
Mecamylamine HCl is supplied as tablets for oral use, each containing 2.5 mg mecamylamine HCl. Inactive ingredients are calcium phosphate, D&C Yellow 10, FD&C Yellow 6, lactose, magnesium stearate, cornstarch, and talc.

A noncompetitive nicotinic AChR inhibitor.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P301+P330+P331+P310
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 36/37/39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: RB6900000
• HazardClass: 6.1
• HS Code: 2921300000