Metforminhydrochloride , 10mMinDMSO , 1115-70-4
Synonym(s):
1,1-Dimethylbiguanide hydrochloride;1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII;Metformin;Metformin - CAS 1115-70-4 - Calbiochem
CAS NO.：1115-70-4
Empirical Formula: C4H12ClN5
Molecular Weight: 165.62
MDL number: MFCD00012582
EINECS: 214-230-6
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 223-226 °C(lit.) |
| Density | 1.36[at 20℃] |
| vapor pressure | 0.001Pa at 25℃ |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, slightly soluble in alcohol, practically insoluble in acetone and in methylene chloride |
| pka | 12.4[at 20 ℃] |
| form | Powder |
| color | White |
| Water Solubility | Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM). |
| λmax | 233nm(H2O)(lit.) |
| Merck | 14,5938 |
| BCS Class | 3 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. |
| InChIKey | OETHQSJEHLVLGH-UHFFFAOYSA-N |
| LogP | -3.5 at 20℃ |
Description and Uses
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.
1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-36/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-45-36/37-16-7 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | DU1800000 |
| HS Code | 29252900 |
| Toxicity | LD50 in rats (mg/kg): 1000 orally, 300 s.c. (Rx Bulletin) |
