2,4,5-Trifluorophenylacetic Acid , 98% , 209995-38-0
CAS NO.：209995-38-0
Empirical Formula: C8H5F3O2
Molecular Weight: 190.12
MDL number: MFCD00082479
EINECS: 466-070-3
| Pack Size | Price | Stock | Quantity |
| 1G | RMB20.00 | In Stock |
|
| 5G | RMB24.00 | In Stock |
|
| 25G | RMB77.60 | In Stock |
|
| 100G | RMB211.20 | In Stock |
|
| 500g | RMB799.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 121-125 °C |
| Boiling point: | 255.0±35.0 °C(Predicted) |
| Density | 1.468±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.78±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C8H5F3O2/c9-5-3-7(11)6(10)1-4(5)2-8(12)13/h1,3H,2H2,(H,12,13) |
| InChIKey | YSQLGGQUQDTBSL-UHFFFAOYSA-N |
| SMILES | C1(CC(O)=O)=CC(F)=C(F)C=C1F |
Description and Uses
2,4,5-Trifluorophenylacetic acid is a fluorophenylacetic acid, which is a valuable intermediate for preparing various pharmacologically active compounds. In particular, trifluorophenylacetic acids are used to prepare inhibitors of the dipeptidyl peptidase-4 enzyme. These medicines are helpful in treating diabetes, in particular type 2 diabetes. One of these active ingredients is Sitagliptin, available commercially under the brand name Januvia, which uses 2,4,5-trifluorophenylacetic acid as a critical intermediate for its synthesis.
2,4,5-Trifluorobenzeneacetic Acid is used in the synthesis of EGFR/ErbB-2-kinase inhibitors. Also used in the synthesis of new imidazopyrazinone derivatives as potnetial dipeptidyl peptidase IV inhibitors.
Safety
| Symbol(GHS) |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H315-H318-H335 |
| Precautionary statements | P280-P302+P352-P305+P351+P338+P310 |
| Hazard Codes | Xi |
| Risk Statements | 37/38-41 |
| Safety Statements | 26-39 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29163990 |
