Tamoxifen citrate salt , 99% , 54965-24-1

Synonym(s):
TMX;TXNDC;TXNDC1;(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene;Estrogen Receptor Signaling Regulator I

CAS NO.：54965-24-1

Empirical Formula: C32H37NO8

Molecular Weight: 563.64

MDL number: MFCD00058321

EINECS: 259-415-2

PRODUCT Properties

• Melting point: 140-144 °C
• storage temp.: 2-8°C
• solubility: methanol: soluble50mg/mL, clear, colorless
• form: Powder
• color: White to off-white
• Water Solubility: slightly soluble
• Sensitive: Light Sensitive & Hygroscopic
• Merck: 14,9048
• BCS Class: 1
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
• InChIKey: FQZYTYWMLGAPFJ-OQKDUQJOSA-N
• SMILES: C(/C1=CC=CC=C1)(\C1C=CC(OCCN(C)C)=CC=1)=C(/CC)\C1=CC=CC=C1.C(O)(C(=O)O)(CC(=O)O)CC(=O)O
• CAS DataBase Reference: 54965-24-1(CAS DataBase Reference)
• EPA Substance Registry System: Tamoxifen citrate (54965-24-1)

Description and Uses

Tamoxifen is a non-steroidal compound with structural similarities to diethylstilbestrol. Tamoxifen citrate is an estrogen receptor antagonist/partial agonist. Induces oxidative stress and apoptosis in estrogen receptor-negative cancer cell lines. Displays neuroprotective effects in permanent focal ischemia. Inhibits PKC. Potent agonist at GPR30 (membrane estrogen receptor). Clinically useful breast cancer agent.

anti-estrogen, protein kinase C inhibitor, beneficial cardiovascular effects, bone cancer treatment, induces DNA adduct formation

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H302-H350-H360D-H410
• Precautionary statements: P201-P202-P264-P273-P301+P312-P308+P313
• Hazard Codes: T,Xi
• Risk Statements: 45-60-61-22-64-36/37/38
• Safety Statements: 53-36/37/39-45-36-26
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: KH2387000
• HazardClass: IRRITANT
• HS Code: 29225090
• Toxicity: LD50 in mice, rats (mg/kg): 200, 600 i.p.; 62.5, 62.5 i.v.; 3000-6000, 1200-2500 orally (Furr, Jordan)