S-Trityl-L-cysteine , 97% , 2799-07-7

Synonym(s):
S-Trityl-L-cysteine

CAS NO.：2799-07-7

Empirical Formula: C22H21NO2S

Molecular Weight: 363.47

MDL number: MFCD00002611

EINECS: 218-195-8

PRODUCT Properties

• Melting point: 182-183 °C (dec.)(lit.)
• Boiling point: 524.7±50.0 °C(Predicted)
• Density: 1.1342 (rough estimate)
• refractive index: 111 ° (C=0.8, 0.04mol Ethanolic HCl)
• storage temp.: Sealed in dry,Room Temperature
• solubility: Soluble in DMSO (up to 20 mg/ml).
• form: White to off-white solid.
• pka: 2.22±0.10(Predicted)
• color: White or off-white
• optical activity: [α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl
• BRN: 2339626
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
• CAS DataBase Reference: 2799-07-7(CAS DataBase Reference)

Description and Uses

S-Trityl-cysteine (2799-07-7) is a cell permeable inhibitor of mitotic kinesin Eg5 (IC50 for inhibition of basal ATPase activity = 1 μM; IC50 for inhibition of microtubule-activated ATPase activity = 140 nM). Mean growth concentration (GI50) of 1.31 μM for a panel of 60 different tumor cell lines.

(+)-S-Trityl-L-cysteine, a non-natural, sulfur-containing amino acid is commonly used as a reagent in solution phase peptide synthesis (SPPS). It is also used as a metal-binding agent to synthesize substituted ferrocenoyl peptide conjugates using HBTU peptide coupling reagent for the cation-sensing applications solution via peptide-metal interactions.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312+P330-P501-P301+P312a-P330-P501a
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: AY7710000
• HS Code: 29309090
• Toxicity: dog,LDLo,intravenous,150mg/kg (150mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),National Technical Information Service. Vol. PB81-109993,