L-p-Bromotetramisoleoxalate , 10mMinDMSO , 62284-79-1

Synonym(s):
(−)-4-Bromotetramisole oxalate;(-)-4-Bromotetramisole oxalate;S(−)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate;6-Bromolevamisole oxalate;S(-)-6-(4-Bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole oxalate

CAS NO.：62284-79-1

Empirical Formula: C13H13BrN2O4S

Molecular Weight: 373.22

MDL number: MFCD00070406

EINECS: 263-487-0

PRODUCT Properties

• Melting point: 192 °C (dec.) (lit.)
• Flash point: 87℃
• storage temp.: 2-8°C
• solubility: Soluble in Water (up to 10 mg/ml)
• form: liquid
• color: White
• optical activity: [α]25/D 104°, c = 0.5 in H2O
• BRN: 4944883
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.

Description and Uses

Four distinct human isoenzymes of alkaline phosphatase (AP) are known: intestinal (IAP), placental (PLAP), tissue non-specific (NSAP, also known as liver/bone/kidney AP), and germ cell AP (also known as placental-like AP, PLAP-like). L-p-Bromotetramisole is a cell-permeable inhibitor of all four human AP isoenzymes (K_is =18 and 56 μM for PLAP and NSAP, respectively). While PLAP is strongly inhibited by L-p-bromotetramisole, a second AP, possibly PLAP-like, shows only partial inhibition. L-p-Bromotetramisole has been shown to inhibit a tyrosine phosphatase from Drosophila and, as a result, is also used as a tyrosine phosphatase inhibitor.

L-p-Bromotetramisole Oxalate or (-)-p-Bromotetramisole Oxalate is a potent inhibitor of alkaline phosphatase.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H312
• Precautionary statements: P264-P270-P280-P301+P312-P302+P352+P312-P362+P364
• Hazard Codes: Xn
• Risk Statements: 21/22-36/37/38-20/21/22
• Safety Statements: 24/25-36/37/39-26
• WGK Germany: 3
• F: 10