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A7634658

Flubendazole , 2mMinDMSO , 31430-15-6

Synonym(s):
Flubendazol;Flubendazole;Flumoxanal;Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate

CAS NO.:31430-15-6

Empirical Formula: C16H12FN3O3

Molecular Weight: 313.28

MDL number: MFCD00871999

EINECS: 250-624-4

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 290°C
Density  1.3720 (estimate)
storage temp.  2-8°C
solubility  Practically insoluble in water, in alcohol and in methylene chloride
pka 10.66±0.10(Predicted)
form  Solid
color  White to Off-White
Merck  14,4118
CAS DataBase Reference 31430-15-6(CAS DataBase Reference)

Description and Uses

Flubendazole is a benzimidazole carbamate anthelmintic. It completely eliminates larvae in a mouse model of A. cantonensis infection and exhibits a mean larval reduction of 100% in a T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. Flubendazole inhibits mammalian tubulin polymerization (IC50 = 2.5 μM) and inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50 = 0.17 μM). Flubendazole also inhibits the proliferation of BT-549, SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells (IC50s = 0.72, 1.51, 1.75, and 5.51 μM, respectively) and reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at a dose of 25 mg/kg.

An insectocidal agent.

Safety

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361
Precautionary statements  P201-P202-P281-P308+P313-P405-P501
Risk Statements  22
Safety Statements  44
WGK Germany  2
RTECS  DD6497500
HS Code  29339900
Toxicity LD50 in mice, rats, guinea pigs (mg/kg): >2560 orally (Thienpont)

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