EthacrynicAcid , 10mMinDMSO , 58-54-8
Synonym(s):
Ethacrynic acid;ECA;Etacrynic acid;(2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid;[2,3-Dichloro-4-(2-ethylacryloyl)phenoxy]acetic acid
CAS NO.：58-54-8
Empirical Formula: C13H12Cl2O4
Molecular Weight: 303.14
MDL number: MFCD00056693
EINECS: 200-384-1
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 125 °C |
| Boiling point: | 480.0±45.0 °C(Predicted) |
| Density | 1.3562 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| pka | 3.50(at 25℃) |
| color | white to beige |
| Water Solubility | Soluble in ethanol, chloroform, ether, ammonia, carbonates, and methanol. Insoluble in water. |
| Merck | 3717 |
| CAS DataBase Reference | 58-54-8(CAS DataBase Reference) |
| EPA Substance Registry System | Ethacrynic acid (58-54-8) |
Description and Uses
Ethacrynic acid is a loop diuretic with anticancer activity., It inhibits the Na-K-2Cl (NKCC) cotransporter in duck erythrocytes (IC50 = 0.18 mM) and ATP-dependent chloride uptake in rat renal plasma membrane vesicles when used at a concentration of 0.3 mM., Ethacrynic acid also inhibits glutathione S-transferase P1-1 (GSTP1-1) and GSTA3-3 (IC50s = 4.9 and ~0.4 μM, respectively), and inhibits Wnt/β-catenin signaling in a cell-based reporter assay. It is cytotoxic to primary chronic lymphocytic leukemia cells (IC50 = 8.56 μM), as well as MCF-7, MDA-MB-231, and 4T1 cancer cells (IC50s = 45.53, 39.64, and 25.23 μM, respectively). Ethacrynic acid (250 μg per day) increases tumor growth reduction induced by the EGFR family inhibitors afatinib (Item Nos. 11492 | 21567) or neratinib in a 4T1 murine breast cancer model. Formulations containing ethacrynic acid have been used in the treatment of edema.
Ethacrynic acid is a powerful diuretic prescribed for edema associated with cardiac insufficiency, renal edema that does not respond to other diuretics, and edema of the brain and lungs.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312+P330-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | AG6600000 |
| HS Code | 2918992090 |
| Hazardous Substances Data | 58-54-8(Hazardous Substances Data) |
| Toxicity | LD50 in mice (mg/kg): 176 i.v.; 627 orally (Peck) |
