Hydrocortisone21-acetate , 10mMinDMSO , 50-03-3

Synonym(s):
11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-acetate;17-α-Hydroxycorticosterone acetate;17-Hydroxycorticosterone 21-acetate;21-Acetoxy-4-pregnene-11β,17α-diol-3,20-dione;4-Pregnene-11β,17α,21-triol-3,20-dione 21-acetate

CAS NO.：50-03-3

Empirical Formula: C23H32O6

Molecular Weight: 404.5

MDL number: MFCD00037714

EINECS: 200-004-4

PRODUCT Properties

• Melting point: 223 °C (dec.)(lit.)
• Boiling point: 446.1°C (rough estimate)
• alpha: D25 +166° (c = 0.4 in dioxane); D25 +150.7° (c = 0.5 in acetone)
• Density: d420 1.289
• refractive index: 1.4593 (estimate)
• Flash point: 223°C
• storage temp.: 0-6°C
• solubility: Practically insoluble in water, slightly soluble in anhydrous ethanol and in methylene chloride
• form: Solid
• pka: 12.42±0.70(Predicted)
• color: White to Off-White
• Water Solubility: Insoluble in water.
• Decomposition: 223 ºC
• Merck: 14,4787
• BRN: 2066841
• Stability: Stable, but may be light or moisture sensitive. Incompatible with strong oxidizing agents.
• LogP: 2.190

Description and Uses

Hydrocortisone acetate is used to treat hemorrhoids and itching/swelling in the rectum and anus. It is used to treat certain intestinal problems (such as ulcerative colitis of the rectum and other rectal/anal inflammatory conditions).

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H360Df-H373
• Precautionary statements: P202-P260-P280-P308+P313-P405-P501
• Hazard Codes: Xn,T
• Risk Statements: 63-10-45
• Safety Statements: 36/37-45-53
• WGK Germany: 3
• RTECS: GM8960000
• HS Code: 29372100
• Toxicity: LD50 intraperitoneal in mouse: 2300mg/kg