Home Categories Biochemical Engineering Gambogicacid
A7620258

Gambogicacid , 10mMinDMSO , 2752-65-0

Synonym(s):
Beta-Guttiferrin;Guttatic acid;Guttic acid;Guttic Acid, β-Guttiferin;Beta-Guttilactone

CAS NO.:2752-65-0

Empirical Formula: C38H44O8

Molecular Weight: 628.75

MDL number: MFCD16878985

Pack Size Price Stock Quantity
1ml RMB756.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 88.5°C
Boiling point: 586.06°C (rough estimate)
alpha  D20 -685° (methanol)
Density  1.1057 (rough estimate)
refractive index  1.5290 (estimate)
storage temp.  -20°C
solubility  DMSO: ≥10mg/mL
form  powder
pka 4.58±0.36(Predicted)
color  yellow to orange
Stability: Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey GEZHEQNLKAOMCA-XKZIYDEJSA-N
LogP 6.490 (est)

Description and Uses

Gambogic acid (2752-65-0) induces apoptosis in a variety of cell lines acting as an antagonist of Bcl-2 family proteins (IC50 < 1 mM)1, however additional targets may contribute to its cytotoxicity. It suppresses cancer invasion and migration by inhibiting TGFb1-induced epithelial-to-mesenchymal transition.2 Potentiates the chemosensitivity of cancer cells to other agents.3 Down-regulates surviving, reversing docetaxel resistance in cancer cells.4

antiinflammatory, cytotoxic, inhibits HeLa cells in vitro;

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P310-P302+P352-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36/37/38
Safety Statements  26-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  1
RTECS  PB9268200
HS Code  29189900
Toxicity LD50 unreported in mammal (species unspecified): 55mg/kg

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