PurvalanolA , 10mMinDMSO , 212844-53-6
Synonym(s):
2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine;2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine;NG-60;Purvalanol A - CAS 212844-53-6 - Calbiochem
CAS NO.：212844-53-6
Empirical Formula: C19H25ClN6O
Molecular Weight: 388.89
MDL number: MFCD02179211
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB784.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 590.5±60.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | methylene chloride: 50 mg/mL, clear, colorless |
| form | powder |
| pka | 14.51±0.10(Predicted) |
| color | off-white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
Description and Uses
Purvalanol A (212844-53-6) is a cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1?Reversibly arrests synchronized cells in G1 and G2 phase.2?Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3?Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4?In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5?Cell permeable.
Purvalanol A acts as a potent, cell-permeable CDK inhibitor used in the treatment of cell proliferative disorders. Anti-cancer.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P261-P280 |
| WGK Germany | 3 |
| HS Code | 2933599590 |
