ParecoxibSodium , 10mMinDMSO , 198470-85-8

CAS NO.：198470-85-8

Empirical Formula: C19H19N2NaO4S

Molecular Weight: 394.42

MDL number:

EINECS: 813-689-5

PRODUCT Properties

• Melting point: 273-275°C
• storage temp.: Inert atmosphere,2-8°C
• solubility: DMF: 10mg/mL; DMSO: 15mg/mL; Ethanol: 3mg/mL; PBS (pH 7.2): 5mg/mL
• form: Powder
• color: White to off-white
• InChI: InChI=1S/C19H18N2O4S.Na.H/c1-3-17(22)21-26(23,24)16-11-9-14(10-12-16)18-13(2)25-20-19(18)15-7-5-4-6-8-15;;/h4-12H,3H2,1-2H3,(H,21,22)
• InChIKey: OGSQVUBPCQXSGW-UHFFFAOYSA-N
• SMILES: CC1ON=C(C2C=CC=CC=2)C=1C1C=CC(S(=O)(=O)NC(=O)CC)=CC=1.[NaH]

Description and Uses

Parecoxib is a prodrug form of the COX-2 inhibitor valdecoxib . It is converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys. Parecoxib is also a cannabinoid (CB) receptor 1 agonist with an EC₅₀ value of 2.4 μM in HEK293 cells. It reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED₅₀ = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED₅₀ = 0.08 mg/kg).

Anti-inflammatory, analgesic.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338