NLG919 , 10mMinDMSO , 1402836-58-1

CAS NO.：1402836-58-1

Empirical Formula: C18H22N2O

Molecular Weight: 282.38

MDL number: MFCD26142661

EINECS: 1592732-453-0

PRODUCT Properties

• Melting point: 143 - 146°C
• Boiling point: 524.6±33.0 °C(Predicted)
• Density: 1.27±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Soluble in DMSO (up to 15 mg/ml)
• pka: 14.85±0.20(Predicted)
• form: solid
• color: White
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Description and Uses

(±)-NLG-919 is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor (K_i = 7 nM; EC₅₀ = 75 nM). (±)-NLG-919 inhibits IDO-induced T cell suppression and restores T cell response during allogenic mixed lymphocyte reactions in vitro (ED₅₀s = 80 and 120 nM, respectively). In vivo, (±)-NLG-919 induces a 95% reduction in tumor volume when administered in conjunction with a pmel-1 T cell vaccine. Formulations containing (±)-NLG-919 are under investigation in clinical trials for treatment of glioblastoma, melanoma, pancreatic, and breast cancers.

NLG919 is a potent indoleamine-2,3-dioxygenase (IDO) pathway inhibitor and is suitable for the treatment of immunosuppression associated with cancer.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302+H312+H332-H315-H319-H335
• Precautionary statements: P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501