PRODUCT Properties
Melting point: | 190-192°C |
alpha | D20 -9° (chloroform) |
Boiling point: | 521.49°C (rough estimate) |
Density | 1.0389 (rough estimate) |
vapor pressure | 0-0Pa at 25℃ |
refractive index | 1.4890 (estimate) |
storage temp. | Sealed in dry,2-8°C |
solubility | Practically insoluble in water, freely soluble in ethanol (96 per cent) |
form | Solid |
pka | pK: 5.35 in water |
color | White to Off-White |
optical activity | -920 (c 1, CHCl3) |
Water Solubility | 2.376-525000μg/L at 25℃ |
λmax | 204nm(H2O)(lit.) |
Merck | 14,4317 |
Stability: | Hygroscopic |
LogP | 2.68-6.75 at 20℃ |
Description and Uses
Fusidic acid was found in the culture broth of a fungus imperfectus, Fusidium coccineum, by Leo in 1962. It has a steroid struc ture but shows no hormonal activity.
Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Dyes and metabolites.