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A7587458

GalantamineHydrobromide , 10mMinWater , 1953-04-4

Synonym(s):
Galantamine hydrobromide;Galanthamine hydrobromide

CAS NO.:1953-04-4

Empirical Formula: C17H22BrNO3

Molecular Weight: 368.27

MDL number: MFCD00067672

EINECS: 217-780-5

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 256 °C
alpha  D20 -93.1° (c = 0.1015 in 15 ml H2O)
refractive index  -95 ° (C=1.4, H2O)
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  Sparingly soluble in water, very slightly soluble in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
form  White to off-white crystalline solid.
color  White to Orange to Green
Water Solubility  Soluble in water or DMSO
Merck  14,4340
InChI InChI=1/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/s3
InChIKey QORVDGQLPPAFRS-ORFATOSYNA-N
SMILES [C@@]123CCN(C)CC4=CC=C(OC)C(O[C@H]1C[C@@H](O)C=C2)=C34.Br |&1:0,14,16,r|
LogP 1.750 (est)
CAS DataBase Reference 1953-04-4(CAS DataBase Reference)

Description and Uses

Galantamine hydrobromide (marketed as Reminyl) is one of a group of three drugs for people with Alzheimer's disease called cholinesterase inhibitors. The other two are called donepezil hydrochloride (common brand name Aricept) and rivastigmine (common brand name Exelon). It is a selective acetylcholinesterase inhibitor that for the treatment and prevention of Alzheimer's disease and other diseases resulting from reduced neuronal metabolism.

Safety

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P405-P501
Hazard Codes  T
Risk Statements  25
Safety Statements  45-36/37/39-22
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  DF8075000
HazardClass  6.1
PackingGroup  II
HS Code  29399990
Toxicity LD50 i.v. in mice (mg/kg): 5.2 ± 0.2 (Friess)

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