3-Indolepropionicacid , 10mMinDMSO , 830-96-6

Synonym(s):
3-(3-Indolyl)propanoic acid;3-(3-Indolyl)propionic acid;Indole-3-propionic acid;IPA

CAS NO.：830-96-6

Empirical Formula: C11H11NO2

Molecular Weight: 189.21

MDL number: MFCD00005660

EINECS: 212-600-1

PRODUCT Properties

• Melting point: ~133 °C
• Boiling point: 82 °C(lit.)
• Density: 0.960 g/mL at 20 °C
• vapor density: 2.1 (vs air)
• vapor pressure: 33 mm Hg ( 20 °C)
• refractive index: n20/D 1.377(lit.)
• Flash point: 53 °F
• storage temp.: Sealed in dry,Room Temperature
• solubility: ethanol: soluble50mg/mL, clear, yellow to orange
• pka: 4.77±0.10(Predicted)
• form: crystalline
• color: light yellow
• Water Solubility: slightly soluble
• BRN: 147733

Description and Uses

Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities. It scavenges ABTS radicals in a cell-free assay when used at concentrations ranging from 50 to 150 μM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC₅₀ = 180 μM). Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells. It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; ) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.

Reactant for preparation of:

• Fluorescent analogues of strigolactones
• Anti-tumor agents
• Melanocortin receptors ligands
• Immunosuppressive agents
• Iinhibitors of hepatitis C virus
• Histamine H4 receptor agonists
• NR2B/NMDA receptor antagonists
• CB1 antagonist for the treatment of obesity
• Antibacterial agents
• Inhibitor of TGF-β receptor binding

Indole-3-propionic acid may be used in the synthesis of oxindole-3-propionic acid via reaction with N-bromosuccinimide in acetic acid followed by treatment with H₂/Pd catalyst.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 22-36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: NM1329000
• F: 8-10-23
• TSCA: Yes
• HS Code: 29339990
• Toxicity: LDLo intraperitoneal in mouse: 100mg/kg