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A7418312

Naproxen , >99.0% , 22204-53-1

Synonym(s):
(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid;(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid;NAP;Naproxen

CAS NO.:22204-53-1

Empirical Formula: C14H14O3

Molecular Weight: 230.26

MDL number: MFCD00010500

EINECS: 244-838-7

Pack Size Price Stock Quantity
5G RMB24.00 In Stock
25G RMB95.20 In Stock
100G RMB196.80 In Stock
500G RMB835.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 152-154 °C (lit.)
alpha  D +66° (in chloroform)
Boiling point: 332.25°C (rough estimate)
Density  1.1450 (rough estimate)
refractive index  67.5 ° (C=1, CHCl3)
Flash point: 9℃
storage temp.  2-8°C
solubility  Practically insoluble in water, soluble in ethanol (96 per cent) and in methanol.
form  powder
pka pKa 4.28± 0.02(H2O,t =25,I=0.01) (Uncertain)
color  White to Almost white
optical activity [α]25/D +66°, c = 1 in chloroform
Water Solubility  Insoluble in water.
Merck  14,6417
BRN  3591067
BCS Class 2
LogP 3.18

Description and Uses

Naproxen is synthesized from 2-methoxynaphthalene and the (+)-isomer obtained by resolution with cinchonidine (61). It was introduced in the United States in 1976 and, as a generic drug, has consistently been among the more popular NSAIDs. It is marketed as the S-(+)-enantiomer, but interestingly, the sodium salt of the (–)-isomer also is on the market as Anaprox. As an inhibitor of prostaglandin biosynthesis, it is 12 times more potent than aspirin, 10 times more potent than phenylbutazone, three to four times more potent than ibuprofen, and four times times more potent than fenoprofen, but it is approximately 300 times less potent than indomethacin.

Being analogous to other drugs of this series, naproxene exhibits analgesic, fever-reducing, and long-lasting anti-inflammatory action. It causes reduction and removal of painful symptoms including joint pain, stiffness, and swelling in the joints. It is used in the same indications as ibuprofen.

Safety

Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Warning
Hazard statements  H302-H315-H319-H335-H361fd-H411
Precautionary statements  P202-P273-P301+P312-P302+P352-P305+P351+P338-P308+P313
Hazard Codes  Xn,T,F
Risk Statements  22-39/23/24/25-23/24/25-11-36/37/38
Safety Statements  36/37-45-16-7-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  UF5275000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29189900
Toxicity LD50 in mice (mg/kg): 435 i.v.; 1234 orally; in rats (mg/kg): 575 i.p.; 534 orally (Roszkowski)

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