SKF-525A Hydrochloride , ≥95% , 62-68-0

Synonym(s):
α-Phenyl-α-propylbenzeneacetic acid 2-(diethylamino)ethyl ester;N,N-Diethylaminoethyl 2,2-diphenylvalerate;Proadifen;SKF-525A;SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem

CAS NO.：62-68-0

Empirical Formula: C23H32ClNO2

Molecular Weight: 389.96

MDL number: MFCD00055151

EINECS: 688-917-8

PRODUCT Properties

• Melting point: 122-123°C
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: Soluble in DMSO (up to 20 mg/ml)
• form: White solid
• color: Lustrous crystals from Me2CO/pet ether
• Water Solubility: Soluble in methanol or water
• Stability: Store in Freezer

Description and Uses

SKF 525A is a widely used, nonspecific cytochrome P (CYP)450 inhibitor that demonstrates 100% inhibition of the various CYP450 isoforms at 1-100 μM. It therefore potentiates the effects of many different drugs by inhibiting their metabolism (IC₅₀ values in the μM range when tested using human liver microsomes). SKF 525A inhibits CYP450-dependent arachidonic acid conversion to active EET metabolites, antagonizing the recovery of functional calcium pools. It also acts as a noncompetitive inhibitor of acetylcholine nicotinic receptors (IC₅₀ = 19 μM in mouse skeletal muscle).

Cytochrome P-459 inhibitor; blocks glibenclamide-sensitive K+ channels; inhibits neuronal nitric oxide synthetase; stimulates endothelial cell prostacyclin while inhibiting platelet thromboxane synthesis

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312a-P330-P501a
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 36-24/25
• WGK Germany: 3
• RTECS: YV7175000
• HS Code: 29221990
• Toxicity: LD50 oral in rat: 2140mg/kg