(S)-(+)-2，2-Dimethyl-4-(hydroxymethyl)-1，3-dioxolane-p-toluenesulfonate , ≥97.0% , 23735-43-5

Synonym(s):
(S)-2,2-Dimethyl-1,3-dioxolane-4-methyl p-toluenesulfonate;L-α,β-Isopropylideneglycerol-γ-tosylate;2,3-Isopropylidene-sn-glycerol 1-tosylate;2,3-Isopropylidene-sn-glycerol 1-tosylate

CAS NO.：23735-43-5

Empirical Formula: C13H18O5S

Molecular Weight: 286.34

MDL number: MFCD00063234

PRODUCT Properties

• Melting point: 29-31 °C
• alpha: 4.2 º (c=10, abs.alcohol)
• Boiling point: 398.71°C (rough estimate)
• Density: 1.208 g/mL at 25 °C(lit.)
• refractive index: n20/D 1.506(lit.)
• Flash point: >230 °F
• storage temp.: Inert atmosphere,2-8°C
• form: powder to lump to clear liquid
• color: White or Colorless to Light yellow
• optical activity: [α]26/D +7.5°, c = 2% in DMF
• BRN: 89799

Description and Uses

(S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate has been used as a reactant for the synthesis of 16-(3-trifluoromethyl)phenoxy PGF2α analog travoprost (T715600) which has potent topical ocular activity. (S)-(+)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate has also been used for the preparation of p38 mitogen activated protein (MAP) kinase inhibitors.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 10-21
• HS Code: 29329990