Sertraline HCl , ≥98%(HPLC) , 79559-97-0

Synonym(s):
(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride;Sertraline HCl;Sertraline hydrochloride

CAS NO.：79559-97-0

Empirical Formula: C17H18Cl3N

Molecular Weight: 342.69

MDL number: MFCD00895772

EINECS: 616-702-0

PRODUCT Properties

• Melting point: 246-249°C
• alpha: D23 +37.9° (c = 2 in methanol)
• Density: 1.37
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: DMSO: ~26 mg/mL
• form: solid
• pka: pKa (water): 9.48 ± 0.04; pKa (methanol:water, 40:60 v/v): 8.6; pKa (ethanol:water, 1:1 v/v): 8.5(at 25℃)
• color: white
• Merck: 14,8467
• Stability: Store in Freezer

Description and Uses

Sertraline is a selective serotonin reuptake inhibitor (SSRI). It inhibits monoamine uptake by the serotonin transporter (SERT) with an IC₅₀ value of 70 nM. It is selective for SERT over the norepinephrine and dopamine transporters (IC₅₀s = 520 and 720 nM, respectively). Sertraline (3.2-56 mg/kg, s.c.) reduces immobility in the forced swim test in mice. Sertraline (5 μM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide. Formulations containing sertraline have been used in the treatment of depression, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), and various anxiety disorders.

A selective ST inhibitor

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H302-H400
• Precautionary statements: P273-P301+P312+P330
• Hazard Codes: Xi,T,F
• Risk Statements: 36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 22-24/25-36-26-45-36/37-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: QJ0352070
• HazardClass: IRRITANT
• HS Code: 29214990