Stattic , ≥98% , 19983-44-9
Synonym(s):
6-Nitrobenzo[b]thiophene-1,1-dioxide;6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound;Stat three inhibitory compound;STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB239.20 | In Stock |
|
| 100MG | RMB679.20 | In Stock |
|
| 250mg | RMB1120.00 | In Stock |
|
| 1g | RMB2248.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 187-188 °C |
| Boiling point: | 461.1±45.0 °C(Predicted) |
| Density | 1.621±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: >20mg/mL |
| form | powder |
| color | white to beige |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
Description and Uses
Stattic (19983-44-9) is a STAT3 inhibitor that inhibits binding of tyrosine-phosphorylated peptides to STAT3 SH2 domain and inhibiting STAT3 activation, dimerization and nuclear translocation.1 Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines. Alkyates four cysteine residues on STAT3.2 Exhibits potent antitumor activity.3 Protects against angiotensin II-induced vascular dysfunction and hypertension.4?Stattic is an extremely useful tool to probe involvement of STAT3 in cellular signaling.
Stattic was used to study Stat3-mediated cell signaling in human lung carcinoma cells.5
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 20/21/22-36/37/38-22 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 2934999090 |
