Sulfamethizole , 98% , 144-82-1

Synonym(s):
N¹-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide;4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide;Sulfamethizole;Sulfamethylthiadiazole

CAS NO.：144-82-1

Empirical Formula: C9H10N4O2S2

Molecular Weight: 270.33

MDL number: MFCD00053363

EINECS: 205-641-1

PRODUCT Properties

• Melting point: 210 °C
• Boiling point: 176°C (rough estimate)
• Density: 1.4704 (rough estimate)
• refractive index: 1.6440 (estimate)
• storage temp.: 2-8°C
• solubility: Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: 5.45(at 25℃)
• color: White to Off-White
• Water Solubility: 529mg/L(20 ºC)
• Merck: 14,8916
• BRN: 255002
• CAS DataBase Reference: 144-82-1(CAS DataBase Reference)
• EPA Substance Registry System: Sulfamethizole (144-82-1)

Description and Uses

Sulfamethizole is a broad spectrum sulfonamide antibiotic (MIC₉₀s = 1.25-5,000 μg/ml against clinical isolates of E. coli and K. pneumoniae). It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.

This drug has antibacterial activity with respect to streptococci, pneumococci, staphylococci, meningococci, gonococci, colon bacillus, pathogenic dysentery, and others. It is not very toxic. It is generally used for acute, uncomplicated infections of the urinary tract that are caused by sensitive organisms. Because it is removed quickly from the organism by the kidneys, the level of drug in the plasma remains low, and therefore it is not used for treating infections that are localized in the urinary tract. Sulfisoxazole is the more preferred drug. Synonyms of this drug are urosol, rufol, thiosulfil, and others.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H317
• Precautionary statements: P280
• Hazard Codes: Xi
• Risk Statements: 43
• Safety Statements: 36/37
• WGK Germany: 2
• RTECS: WP0875000
• HS Code: 2935904000
• Hazardous Substances Data: 144-82-1(Hazardous Substances Data)
• Toxicity: LD50 oral in rat: 3500mg/kg