Sulindac , ≥98% , 38194-50-2

Synonym(s):
(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid

CAS NO.：38194-50-2

Empirical Formula: C20H17FO3S

Molecular Weight: 356.41

MDL number: MFCD00599589

EINECS: 253-819-2

PRODUCT Properties

• Melting point: 182-185°C
• Boiling point: 581.6±50.0 °C(Predicted)
• Density: 1.2581 (estimate)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: Very slightly soluble in water, soluble in methylene chloride, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
• form: Solid
• pka: pKa (25°) 4.7
• color: Light yellow to Brown
• Water Solubility: Soluble in water, methanol, ethanol.
• λmax: 327nm(0.05mol/L methanolic HCl)(lit.)
• Merck: 14,8982
• CAS DataBase Reference: 38194-50-2(CAS DataBase Reference)
• NIST Chemistry Reference: Sulindac(38194-50-2)
• EPA Substance Registry System: 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-, (1Z)- (38194-50-2)

Description and Uses

Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans. Sulindac is one of the older NSAIDs, an isostere of indomethacin developed before the inducible form of COX-2 was discovered. Although a number of NSAIDs have been found to protect against digestive tract cancers, sulindac has an extensive epidemiology documenting reduced human colorectal cancer. In murine models, sulindac was found not only to inhibit the enzymatic activity of polyp-associated COX-2, but also to downregulate the expression of colonic COX-2 protein to control levels.

Sulindac is used for relieving weak to moderate pain in rheumatoid arthritis and osteoarthritis.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H301-H317-H334-H361
• Precautionary statements: P261-P280-P284-P301+P330+P331+P310-P304+P340-P342+P311
• Hazard Codes: Xn
• Risk Statements: 22-63-42/43
• Safety Statements: -
• RIDADR: 3249
• WGK Germany: 3
• RTECS: NK8226000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29309090