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A7364012

Sorafenib , ≥99% , 284461-73-0

CAS NO.:284461-73-0

Empirical Formula: C21H16ClF3N4O3

Molecular Weight: 464.82

MDL number: MFCD06411450

EINECS: 608-209-4

Pack Size Price Stock Quantity
250MG RMB31.20 In Stock
1G RMB48.80 In Stock
5g RMB170.40 In Stock
25g RMB601.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 202-204°C
Boiling point: 523.3±50.0 °C(Predicted)
Density  1.454±0.06 g/cm3(Predicted)
vapor pressure  0Pa at 25℃
storage temp.  Sealed in dry,Store in freezer, under -20°C
solubility  Chloroform (Slightly), DMSO (Slightly)
pka 12.89±0.70(Predicted)
form  White to off-white solid.
color  White to Off-White
Water Solubility  100μg/L at 20℃
LogP 3.3 at 25℃
CAS DataBase Reference 284461-73-0(CAS DataBase Reference)

Description and Uses

Sorafenib is a small molecular inhibitor of several kinases involved in tumor angiogenesis and proliferation, including, but not limited to, Raf (IC50=12nM for Raf-1), VEGFR (IC50=90nM for VEGFR-2 and IC50=12nM for VEGFR-3), and platelet derived growth factor receptor (IC50=57nM for PDGFR-b). Specifically, sorafenib blocks tumor progression by inhibiting cellular proliferation that is dependent on activation of the MAPK pathway (Raf) and/or inhibiting tumor angiogenesis through VEGFR and/or PDGFR. While it may be effective in the treatment of a variety of tumors, the first approvable indication is for renal cell carcinoma. Overall, the drug appears to be well tolerated by the majority of patients at the 400 mg b.i.d. continuous dosing. As an inhibitor of multiple kinases vital for tumor progression, sorafenib may possess wide-spectrum antitumor properties and may emerge as an effective weapon against a variety of solid tumors.

Sorafenib Tosylate (Bay 43-9006, Nexavar) is a small molecular inhibitor of VEGFR, PDGFR, c-Raf and B-Raf with IC50s of 18 nM, 10 nM, 3 nM and 15 nM, respectively.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Risk Statements  68/20/21/22-37/38
Safety Statements  36-37-39
HS Code  29350090
Hazardous Substances Data 284461-73-0(Hazardous Substances Data)

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