A7307512
Streptozocin , 98%(including heterogeneity) , 18883-66-4
Synonym(s):
N-(Methylnitrosocarbamoyl)-α-D -glucosamine;Streptozotocin
CAS NO.：18883-66-4
Empirical Formula: C8H15N3O7
Molecular Weight: 265.22
MDL number: MFCD00006607
EINECS: 242-646-8
| Pack Size | Price | Stock | Quantity |
| 50MG | RMB79.20 | In Stock |
|
| 250MG | RMB163.20 | In Stock |
|
| 1G | RMB583.20 | In Stock |
|
| 5G | RMB2650.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 121 °C (dec.) (lit.) |
| alpha | D25 +39° |
| Boiling point: | 408.44°C (rough estimate) |
| Density | 1.4410 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Water (up to 25 mg/ml) |
| form | powder |
| pka | pKa 1.3 (Uncertain) |
| color | white to light yellow |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| Merck | 13,8912 |
| BRN | 2060675 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
| InChIKey | ZSJLQEPLLKMAKR-FEQHFJGESA-N |
| CAS DataBase Reference | 18883-66-4 |
| IARC | 2B (Vol. 17, Sup 7) 1987 |
| EPA Substance Registry System | Streptozotocin (18883-66-4) |
Description and Uses
Streptozotocin (STZ) was originally identified in the late 1950s as an antibiotic and was discovered in a strain of the soil microbe Streptomyces achromogenes. In the mid-1960s, STZ was found to be selectively toxic to the beta cells of the pancreatic islets and thus it is used in animal model of diabetes and as a medical treatment for cancers of the beta cells. STZ’s use in cancer chemotherapy received Food and Drug Administration approval in July 1982 and the drug was subsequently marketed as Zanosar.
antineoplastic, alkylating agent
Safety
| Symbol(GHS) |   GHS02,GHS08 |
| Signal word | Warning |
| Hazard statements | H228-H341-H351 |
| Precautionary statements | P201-P202-P210-P240-P241-P308+P313 |
| Hazard Codes | Xn,T |
| Risk Statements | 40-61-46-45-22-20/21/22 |
| Safety Statements | 36/37-53-45-36-22 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | LZ5775000 |
| F | 3-10-21 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29419090 |
| Hazardous Substances Data | 18883-66-4(Hazardous Substances Data) |
| Toxicity | LD50 in female mice (mg/kg): 360 i.p.; 275 i.v.; in male dogs (mg/kg): 50 i.v. (Iwasaki) |
