Salicylamide , 99% , 65-45-2

Synonym(s):
2-Hydroxybenzamide;Salicylamide

CAS NO.：65-45-2

Empirical Formula: C7H7NO2

Molecular Weight: 137.14

MDL number: MFCD00007978

EINECS: 200-609-3

PRODUCT Properties

• Melting point: 140-144 °C(lit.)
• Boiling point: 270°C
• Density: 1,175 g/cm³
• refractive index: 1.5323 (estimate)
• Flash point: 181°C/14mm
• storage temp.: Inert atmosphere,Room Temperature
• solubility: methanol: 0.1 g/mL, clear
• pka: pKa 8.13(H2O t = 37) (Uncertain)
• form: Crystalline Powder
• color: White
• Odor: Odorless
• PH Range: 5 (0.2% aq soln)
• Water Solubility: <0.1 g/100 mL at 20 ºC
• Decomposition: 270°C
• Merck: 14,8328
• BRN: 742439
• Stability: Stable. Light sensitive. Incompatible with strong bases, strong oxidizing agents.
• InChIKey: SKZKKFZAGNVIMN-UHFFFAOYSA-N
• LogP: 1.280

Description and Uses

Salicylamide is less acidic (pKa 8.2) than other salicylic acid derivatives. Although poorly soluble in water, stable solutions can be formed at pH 9 through ionization of the phenolic group. It is absorbed from the GI tract on oral administration and is rapidly metabolized to inactive metabolites by intestinal mucosa, but not by hydrolysis. Activity appears to reside in the intact molecule. Salicylamide is approximately 40 to 55% plasma protein bound, and it competes with other salicylates and acetaminophen for glucuronide conjugation, decreasing the extent of conjugation of these other drugs.

Medicine (analgesic).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38-20/21/22
• Safety Statements: 26-36
• RIDADR: 3249
• WGK Germany: 3
• RTECS: VN6475000
• TSCA: Yes
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29214300
• Toxicity: LD50 orally in mice: 1.4 g/kg (Hart)