Schizandrol B , Analysis of standards,> 98% , 58546-54-6
| Pack Size | Price | Stock | Quantity |
| 25MG | RMB223.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 88.5°C |
| Boiling point: | 454.79°C (rough estimate) |
| Density | 1.1772 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO : 50 mg/mL (120.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| form | powder to crystal |
| pka | 14.58±0.40(Predicted) |
| color | White to Light yellow |
| LogP | 4.770 (est) |
Description and Uses
Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity. It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells. It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen .
Schizandrol B exhibits potent protective effects of on ET-1-induced dysfunctional human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). Anti-cholestasis effect.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P501-P270-P264-P301+P312+P330 |
| Safety Statements | 24/25 |
| HS Code | 29329990 |
