Home Categories Biochemical Engineering D-Serine
A7285112

D-Serine , >98.5% , 312-84-5

Synonym(s):
β-Hydroxyalanine;(R)-2-Amino-3-hydroxypropionic acid;Ser

CAS NO.:312-84-5

Empirical Formula: C3H7NO3

Molecular Weight: 105.09

MDL number: MFCD00004269

EINECS: 206-229-4

Pack Size Price Stock Quantity
25G RMB44.00 In Stock
100G RMB69.60 In Stock
500G RMB263.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 220 °C
alpha  -14.75 º (c=10 2 N HCl)
Boiling point: 197.09°C (rough estimate)
Density  1.3895 (rough estimate)
refractive index  1.4368 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  H2O: 0.1 g/mL, clear, colorless
form  Crystalline Powder
pka 2.16±0.10(Predicted)
color  White
Water Solubility  346 g/L (20 ºC)
Merck  14,8460
BRN  1721403
InChIKey MTCFGRXMJLQNBG-UWTATZPHSA-N
LogP -1.490 (est)

Description and Uses

Serine is one of the 20 naturally-occurring amino acids used by all organisms in the biosynthesis of proteins. Having a single chiral center, serine can exist as one of two stereoisomers (L-Serine and D-Serine).
D-serine is categorized as a nootropic. It is an amino acid found in the brain and is produced primarily in astrocytes; the conversion of L-serine to D-serine is catalyzed by the serine racemase enzyme. D-serine acts as a co-agonist of glutamate NMDA receptors and binds at the glycine site. NMDA receptors mediate synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition, and learning. Schizophrenia is characterized by reduced NMDA receptor signaling and therefore, D-serine supplementation has been tested extensively in patients with schizophrenia. It is thought to improve cognitive symptoms in this population. It is worth noting that in Alzheimer’s disease, there is excess glutamate receptor activation. Memantine, one of the drugs used to treat Alzheimer’s disease, is an NMDA receptor antagonist.

D-serine has been used as a substrate in D-amino acid oxidase (DAO) activity in human 1321N1 astrocytoma cells. It has also been used in intracerebroventricular administration in rat for the induction of antinociceptive effect.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  3
RTECS  VT8200000
TSCA  Yes
HS Code  29225000

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