Sinomenine Hydrochloride , Analysis of standard products, ≥97% , 6080-33-7

Synonym(s):
(9a,13a,14a)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one hydrochloride;Cucoline hydrochloride;Kukolin hydrochloride

CAS NO.：6080-33-7

Empirical Formula: C19H24ClNO4

Molecular Weight: 365.85

MDL number: MFCD01714307

PRODUCT Properties

• Melting point: 231.0 to 235.0 °C
• storage temp.: Inert atmosphere,2-8°C
• solubility: H2O: soluble20mg/mL, clear
• form: powder
• color: white to beige
• optical activity: [α]/D -70 to -90°, c = 1 in H2O
• Water Solubility: Soluble to 100 mM in water

Description and Uses

Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events. Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain. It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein.

Sinomenine is an optical isomer of Methoxythebainone. Sinomenine was extracted from root of Sinomenium acutum. Sinomenine has anti-inflammatory and analgesic effect.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302+H312+H332-H315-H319-H335-H351
• Precautionary statements: P201-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312-P308+P313
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: QD2163000
• HS Code: 29334900