Syringin , Analysis of standard products, ≥98% , 118-34-3
Synonym(s):
Syringin;Magnolenin;Syringoside;Methoxyconiferine;Sinapyl alcohol 4-O-glucoside
CAS NO.：118-34-3
Empirical Formula: C17H24O9
Molecular Weight: 372.37
MDL number: MFCD00016778
EINECS: 601-519-0
| Pack Size | Price | Stock | Quantity |
| 20MG | RMB665.60 | In Stock |
|
| 100mg | RMB2563.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 192°C |
| Boiling point: | 421.84°C (rough estimate) |
| Density | 1.2870 (rough estimate) |
| refractive index | 1.6230 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly) |
| form | Solid |
| pka | 12.75±0.70(Predicted) |
| color | White to Off-White |
| BRN | 97166 |
| InChIKey | QJVXKWHHAMZTBY-GCPOEHJPSA-N |
| LogP | -1.550 (est) |
| CAS DataBase Reference | 118-34-3 |
| EPA Substance Registry System | Syringin (118-34-3) |
Description and Uses
Syringin is a phenylpropanoid glycoside first isolated from A. senticosus that enhances acetylcholine release in pancreatic cells leading to an increase in insulin release through the muscarinic M3 receptor. Syringin dose-dependently (50, 75, and 100 μg/kg, i.v.) decreases plasma glucose levels and increases insulin-like immunoreactivity and C-peptide in rats, and these effects last at least 60 minutes. In a rat model of type 1 diabetes, it decreases plasma glucose and increases β-endorphin release from the adrenal medulla. Syringin increases autophagy through AMP-activated protein kinase α (AMPKα) activation concomitant with preventing the progression of cardiac hypertrophy in mice following aortic banding. It also has immunomodulatory effects, likely due to its metabolite sinapyl alcohol.
Syringin is a chemical that is found naturally in various plants such as Araliaceae, a adaptogenic agent with Syringin as the active componet. Syringin have exhibited the ability to enhance glucose utilization and the lowering of plasma glucose level in rats suffering from insulin deficiency, suggesting that this chemical may be useful in the treatment of human diabetes.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29329990 |
