R406 (free base) , ≥99% , 841290-80-0
Synonym(s):
;Syk Inhibitor VI, R406 - CAS 841290-80-0 - Calbiochem
CAS NO.：841290-80-0
Empirical Formula: C22H23FN6O5
Molecular Weight: 470.45
MDL number: MFCD09970820
EINECS: 617-533-5
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB375.20 | In Stock |
|
| 10MG | RMB748.80 | In Stock |
|
| 25mg | RMB1279.20 | In Stock |
|
| 50MG | RMB2743.20 | In Stock |
|
| 100mg | RMB3839.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 182-184°C |
| Density | 1.358±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.63±0.40(Predicted) |
| color | Off-White to Light Grey |
Description and Uses
R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce immune complex-mediated inflammation. In cancers characterized by over-expression of Syk, R406 can prevent signaling downstream of Syk and induce apoptosis. R406 also inhibits Syk-dependent signaling through c-Jun N-terminal kinase in rheumatoid arthritis synoviocytes, suggesting a therapeutic intervention in this autoimmune disease.[Cayman Chemical]
Safety
| Symbol(GHS) |   GHS08,GHS06 |
| Signal word | Danger |
| Hazard statements | H301-H361 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P201-P202-P281-P308+P313-P405-P501 |
