Home Categories API Retinoic acid
A7116612

Retinoic acid , Analysis standard , 302-79-4

Synonym(s):
Tretinoin;Retinoic acid;ATRA;Vitamin A acid;Tretinoin, ATRA, Vitamin A Acid

CAS NO.:302-79-4

Empirical Formula: C20H28O2

Molecular Weight: 300.44

MDL number: MFCD00001551

EINECS: 206-129-0

Pack Size Price Stock Quantity
250MG RMB479.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 180-181 °C (lit.)
Boiling point: 381.66°C (rough estimate)
Density  1.0597 (rough estimate)
refractive index  1.4800 (estimate)
storage temp.  -20°C
solubility  Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
form  powder
pka 4.73±0.33(Predicted)
color  yellow
Water Solubility  insoluble
Sensitive  Light Sensitive
Merck  14,8165
BRN  2057223
Stability: Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months.
InChIKey SHGAZHPCJJPHSC-ZVCIMWCZSA-N
LogP 6.300
CAS DataBase Reference 302-79-4(CAS DataBase Reference)
EPA Substance Registry System Retinoic acid (302-79-4)

Description and Uses

all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC50 values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC50s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid (17 nmol) reduces papilloma formation induced by phorbol 12-myristate 13-acetate (TPA; ) in mice. It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis. all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.

retinoic acid (tretinoin) is a vitamin A derivative. It has demonstrated an ability to alter collagen synthesis, increase dermal hyaluronic acid levels, and stimulate fibroblast growth and the extracellular matrix. It is used for keratinization disorders and for treating acne. Retinoic acid’s anti-aging effect has been convincingly documented and it is often used for treating the visible signs of aging, though these results can take approximately 6 months to be visible. It is associated with a number of adverse effects, including irritation, photosensitivity, skin dryness, redness, and peeling. It should also not be used while pregnant.

Safety

Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H302-H315-H360FD-H410
Precautionary statements  P202-P264-P273-P301+P312-P302+P352-P308+P313
Hazard Codes  T,Xn,N
Risk Statements  22-63-38-20/21/22-51/53
Safety Statements  53-26-36/37/39-45-36/37-61-24/25
RIDADR  3249
WGK Germany  3
RTECS  VH6475000
7-8-16-23
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29362100
Hazardous Substances Data 302-79-4(Hazardous Substances Data)
Toxicity LD50 (10 day) in mice, rats (mg/kg): 790, 790 i.p.; 2200, 2000 orally (Kamm)

RELATED PRODUCTS