Retinyl acetate , USP/EP , 127-47-9

Synonym(s):
Retinol acetate;Retinyl acetate;Retinyl acetate solution;Vitamin A acetate;Vitamin A acetate solution

CAS NO.：127-47-9

Empirical Formula: C22H32O2

Molecular Weight: 328.49

MDL number: MFCD00019413

EINECS: 204-844-2

PRODUCT Properties

• Melting point: 57-58 °C
• Boiling point: 406.22°C (rough estimate)
• Density: 1.0474 (rough estimate)
• refractive index: 1.547-1.555
• Flash point: 14℃
• storage temp.: 2-8°C
• solubility: absolute ethanol: 25 mg/mL
• form: solid or viscous liquid
• color: Yellow powder
• Odor: Amine like
• Water Solubility: soluble
• Sensitive: Light & Air Sensitive & Hygroscopic
• Merck: 14,10013
• BRN: 1915439
• Stability: Hygroscopic, Light Sensitive
• InChIKey: QGNJRVVDBSJHIZ-QHLGVNSISA-N
• LogP: 9.4 at 25℃
• CAS DataBase Reference: 127-47-9(CAS DataBase Reference)
• NIST Chemistry Reference: Retinol, acetate(127-47-9)
• EPA Substance Registry System: Retinol acetate (127-47-9)

Description and Uses

Retinyl acetate (retinol acetate, vitamin A acetate,127-47-9) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.

vitamin precursor

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H360-H413
• Precautionary statements: P201-P280-P308+P313
• Hazard Codes: Xn,Xi,T,F
• Risk Statements: 38-63-36/37/38-53-61-11
• Safety Statements: 36/37-45-37/39-26-53-16
• RIDADR: UN1170 - class 3 - PG 2 - Ethanol
• WGK Germany: 2
• RTECS: VH6825000
• F: 1-8-10
• TSCA: Yes
• HS Code: 29362100
• Toxicity: LD50 (10 day) orally in mice: 4100 mg/kg (Kamm)