Home Categories Dyes and Pigments Rose bengal
A7114312

Rose bengal , 90% , 632-69-9

Synonym(s):
Insulin-like growth factor I;Mechano growth factor;Somatomedin-C

CAS NO.:632-69-9

Empirical Formula: C20H5Cl4I4NaO5

Molecular Weight: 997.66

MDL number: MFCD00151169

EINECS: 211-183-3

Pack Size Price Stock Quantity
5G RMB111.20 In Stock
25G RMB285.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >300°C
storage temp.  Store at +15°C to +30°C.
solubility  H2O: soluble1mg/mL
Colour Index  45440
form  Solid
pka 3.9, 4.7(at 25℃)
color  Red-brown
Water Solubility  soluble
Sensitive  Light Sensitive
λmax 548 nm
Merck  14,8262
BRN  3645857
Biological Applications Apoptosis assay; diagnosis of diseases related to amyloid accumulation; controlling plant diseases; identifying fungi; treating skin,mouth,digestive tract,urinary tract,reproductive tract,respiratory tract,circulatory system
CAS DataBase Reference 632-69-9(CAS DataBase Reference)
EPA Substance Registry System Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium salt (632-69-9)

Description and Uses

Rose bengal is a xanthene dye, fluorescein derivative, and photosensitizer. It exhibits absorption/emission maxima of 548/567 nm, respectively. Rose bengal binds to S. aureus cells and decreases survival of photoirradiated S. aureus to 0.012% when used at a concentration of 1 μM. It generates singlet oxygen when exposed to photoirradiation in cell-free assays and induces potassium ion leakage from S. aureus and bovine erythrocytes in the presence of photoirradiation. Rose bengal inhibits the cytochrome P450 (CYP) isoform CYP3A4/5 and the UDP-glucuronosyltransferase (UGT) isoform UGT1A6 in human liver microsomes in a light-dependent manner, with IC50 values of 0.072 and 0.035 μM, respectively, in yellow light, 3.1 and 4.2 μM, respectively, in ambient light, and 3 and 4.2 μM, respectively, in the dark. It has been used for staining of live cells, but exhibits both intrinsic and phototoxicity.

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Safety

Symbol(GHS) 
GHS05
Signal word  Warning
Hazard statements  H290
Precautionary statements  P234-P390
Hazard Codes  Xi
Risk Statements  36-36/38
Safety Statements  22-24/25-37/39-26
RIDADR  UN 3264 8 / PGIII
WGK Germany  3
RTECS  LM5920000
8
TSCA  Yes
HS Code  32129000

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