1,8-Dihydroxy-3-methylanthraquinone , 10mMinDMSO , 481-74-3
Synonym(s):
1,8-Dihydroxy-3-methylanthraquinone;3-Methylchrysazin;Chrysophanic acid
CAS NO.：481-74-3
Empirical Formula: C15H10O4
Molecular Weight: 254.24
MDL number: MFCD00001208
EINECS: 207-572-2
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 194-198 °C |
| Boiling point: | 357.45°C (rough estimate) |
| Density | 1.2693 (rough estimate) |
| refractive index | 1.4872 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | chloroform: soluble1% |
| form | crystalline |
| pka | 6.63±0.20(Predicted) |
| color | yellow-orange |
| Water Solubility | <0.1 g/100 mL at 18 ºC |
| λmax | 429nm(MeOH)(lit.) |
| Merck | 14,2258 |
| BRN | 1252300 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| LogP | 4.720 (est) |
| CAS DataBase Reference | 481-74-3(CAS DataBase Reference) |
| EPA Substance Registry System | Chrysophanic acid (481-74-3) |
Description and Uses
Chrysophanol is an anthraquinone that has been found in R. palmatum and has diverse biological activities. It induces necrosis in J5 human liver cancer cells when used at concentrations of 25, 50, 75, 100, and 200 μM. Chrysophanol (5, 10, and 50 μM) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; ) and inhibits LPS-induced DNA oxidation in BV-2 microglia. In vivo, chrysophanol (5 mg/kg) decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of colitis induced by dextran sulfate (DSS; ). Chrysophanol (0.1, 1, and 10 mg/kg) increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).
A topical ointment used in the treatment of dermal conditions such as eczema and herpes.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/38-36/37/38 |
| Safety Statements | 26-36-37/39 |
| WGK Germany | 3 |
| RTECS | CB6725000 |
| F | 8-10 |
| HS Code | 29146990 |
| Hazardous Substances Data | 481-74-3(Hazardous Substances Data) |
