Quinapril hydrochloride , 98% , 82586-55-8

Synonym(s):
(3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride;Quinapril hydrochloride

CAS NO.：82586-55-8

Empirical Formula: C25H31ClN2O5

Molecular Weight: 474.98

MDL number: MFCD00889215

EINECS: 620-479-5

PRODUCT Properties

• Melting point: 120-130°C
• alpha: D23 +14.5° (c = 1.2 in ethanol) (Klutchko); D25 +15.4° (c = 2 in methanol) (Goel, Krolls)
• storage temp.: 2-8°C
• solubility: H2O: >10mg/mL
• form: solid
• color: white
• CAS DataBase Reference: 82586-55-8(CAS DataBase Reference)

Description and Uses

Quinapril hydrochloride has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on renal tubular epithelial cell proliferation in human renal tubular epithelial cells. It has also been used as an ACE inhibitor to evaluate its effects on the expression of angiotensin II (AII) in patient-derived Atheroma samples.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H303-H361
• Precautionary statements: P201-P202-P270-P281-P301+P312-P308+P313-P403-P501c
• Safety Statements: 22-24/25
• WGK Germany: 2
• RTECS: NW7176000
• HS Code: 2933492250
• Hazardous Substances Data: 82586-55-8(Hazardous Substances Data)
• Toxicity: Freely sol in aq solvents. LD50 in male, female mice, rats (mg/kg): 1739, 1840, 4280, 3541 orally; 504, 523, 158, 107 i.v. (Kaplan, 1989)