Home Categories Pharmaceutical intermediates Quinoline
A7097612

Quinoline , 98% , 91-22-5

Synonym(s):
1-Azanaphthalene;1-Benzazine;2,3-Benzopyridine;Quinoline

CAS NO.:91-22-5

Empirical Formula: C9H7N

Molecular Weight: 129.16

MDL number: MFCD00006736

EINECS: 202-051-6

Update time: 2022-07-08

PRODUCT Properties

Melting point: -17--13 °C (lit.)
Boiling point: 113-114 °C/11 mmHg (lit.) 237 °C (lit.)
Density  1.093 g/mL at 25 °C (lit.)
vapor density  4.5 (vs air)
vapor pressure  0.07 mm Hg ( 20 °C)
refractive index  n20/D 1.625(lit.)
Flash point: 214 °F
storage temp.  Store below +30°C.
solubility  6g/l
pka 4.9(at 20℃)
form  Liquid
color  Purple to dark grey
PH 7.3 (5g/l, H2O, 20℃)
Odor Strong, unpleasant.
explosive limit 1.2-7%(V)
Odor Type medicinal
Water Solubility  slightly soluble
Sensitive  Light Sensitive & Hygroscopic
Merck  14,8068
BRN  107477
Dielectric constant 2.6(-180℃)
Stability: Stable. Incompatible with strong acids, strong oxidizing agents. May discolour on exposure to light. Hygroscopic - protect from moisture. Reacts violently and unpredictably with some materials, especially strong oxidizing agents.
InChIKey SMWDFEZZVXVKRB-UHFFFAOYSA-N
LogP 2.04 at 22℃

Description and Uses

Quinoline is a colourless hygroscopic liquid with characteristic odour. On exposure to light, it turns brown in colour. Quinoline decomposes on heating, and on burning produces toxic fumes including nitrogen oxides. Quinoline reacts with strong oxidants, acids, and anhydrides. Quinoline is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents. Quinoline is combustible. It gives off irritating or toxic fumes (or gases) in a fire. Quinoline is incompatible with strong acids, oxidisers, dinitrogen tetroxide, linseed oil, thionyl chloride, maleic anhydride, and perchromates and reacts violently with most incompatibles. Quinoline is used extensively in the manufacturing of dyes, preparation of hydroxyquinoline sulphate and niacin, as a solvent for resins and terpenes, and as an intermediate in the manufacture of other products.
Quinoline is used mainly as an intermediate in the manufacture of other several products, as a catalyst, as a corrosion inhibitor, in metallurgical processes, in the manufacture of dyes, as a preservative for anatomical specimens, in polymers and agricultural chemicals, and as a solvent for resins and terpenes. Quinoline is also used as an anti-malarial medicine. Because of its solubility in water, quinoline has significant potential for mobility in the environment, which may promote water contamination. Potential exposure to quinoline also occurs from the inhalation of cigarette smoke. Quinoline breaks down quickly in the atmosphere and water.

Quinoline is used in the manufacture of dyesand hydroxyquinoline salts; as a solvent forresins and terpenes; and therapeutically as anantimalarial agent. It occurs in coal tar insmall amounts.

Safety

Symbol(GHS) 
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301-H312-H315-H319-H341-H350-H411
Precautionary statements  P202-P273-P280-P301+P310-P302+P352+P312-P305+P351+P338
Hazard Codes  Xn,N,T
Risk Statements  21/22-38-41-68-40-37/38-51/53-36/38-45
Safety Statements  26-36/37/39-36-23-61-45-53
RIDADR  UN 2656 6.1/PG 3
WGK Germany  2
RTECS  VA9275000
8
Autoignition Temperature 896 °F
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29334900
Toxicity LD50 orally in rats: 460 mg/kg (Smyth)

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