5α-cholestan-3β-ol , 2mMinDMSO , 80-97-7
Synonym(s):
Dihydrocholesterol;β-Cholestanol;5α-Cholestan-3β-ol;3β-Hydroxy-5α-cholestane;5α-Cholestan-3?-ol
CAS NO.：80-97-7
Empirical Formula: C27H48O
Molecular Weight: 388.68
MDL number: MFCD00066413
EINECS: 201-315-8
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 138-142 °C |
| alpha | D22 +24.2° (c = 1.3 in chloroform) |
| Boiling point: | 454.32°C (rough estimate) |
| Density | 0.9506 (rough estimate) |
| refractive index | 1.5250 (estimate) |
| storage temp. | -20°C |
| solubility | chloroform: 0.1 g/mL, clear, colorless |
| form | A solid |
| pka | 15.14±0.70(Predicted) |
| color | White to off-white |
| Water Solubility | Insoluble in water. |
| Merck | 14,2200 |
| BRN | 2418594 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| LogP | 10.065 (est) |
| CAS DataBase Reference | 80-97-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Cholestanol(80-97-7) |
| EPA Substance Registry System | Dihydrocholesterol (80-97-7) |
Description and Uses
Cholestanol is a cholesterol metabolite formed by oxidation and an intermediate in the biosynthesis of chenodeoxycholic acid . Cholestanol (10 μg/ml) induces apoptosis in cornea and lens epithelial cells and increases the activity of IL-1β converting enzyme (ICE) and CPP32 proteases. Dietary administration of 1% cholestanol to mice increases serum and liver cholestanol levels and leads to corneal opacities and gallstones and in rats it leads to cholestanol deposition in the cerebellum. Cholestanol levels are increased in plasma of patients with cerebrotendinous xanthomatosis (CTX), a disease characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.
5alpha-Cholestan-3beta-ol is used as a standard in lipid analysis using HPLC. It acts as a derivitized steroid compound. It is used in agrochemical, pharmaceutical and dyestuff field .
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H302-H315-H319-H331-H336-H351-H361d-H372 |
| Precautionary statements | P261-P281-P305+P351+P338-P311 |
| Hazard Codes | Xn |
| Risk Statements | 22-38-40-48/20/22-67-36/38-20-63 |
| Safety Statements | 24/25-36/37-22-26 |
| RIDADR | UN 1888 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | FZ6350000 |
| TSCA | Yes |
| HS Code | 2906 13 10 |
