Angelicin , 10mMinDMSO , 523-50-2

Synonym(s):
2H-Furo[2,3-h]-1-benzopyran-2-one;2-Oxo-(2H)-furo(2,3-h)-1-benzopyran;Isopsoralen;NSC 404563

CAS NO.：523-50-2

Empirical Formula: C11H6O3

Molecular Weight: 186.16

MDL number: MFCD00064930

EINECS: 637-055-0

PRODUCT Properties

• Melting point: 132-134°C
• Boiling point: 104°C/4mmHg(lit.)
• Density: 1.2477 (rough estimate)
• refractive index: 1.6310 (estimate)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• form: Solid
• color: White
• λmax: 302nm(EtOH)(lit.)
• BRN: 153970
• LogP: 2.080
• CAS DataBase Reference: 523-50-2(CAS DataBase Reference)
• IARC: 3 (Vol. 40, Sup 7) 1987
• NIST Chemistry Reference: 2H-furo[2,3-h]-1-benzopyran-2-one(523-50-2)

Description and Uses

Angelicin is a furanocoumarin typically isolated from the seeds of P. corylifolia. Like other furanocoumarins, angelicin has antibacterial activities against a number of Gram (+) and Gram (-) bacteria. It has also been shown to prevent tacrine-induced cytotoxicity in human liver-derived HepG2 cells (EC₅₀ = 47 μg/ml) and vascular relaxation in phenylephrine-precontracted rat aorta. Angelicin also weakly inhibits topoisomerase II (IC₅₀ = 404 μM).

Antifungal

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P301+P312+P330-P302+P352-P305+P351+P338
• Hazard Codes: Xn,Xi
• Risk Statements: 20/21/22-36/37/38-40
• Safety Statements: 26-36/37/39-37/39-36
• WGK Germany: 3
• RTECS: LV0940000
• HS Code: 29322090
• Hazardous Substances Data: 523-50-2(Hazardous Substances Data)