Ammoniumpyrrolidinedithiocarbamate , 10mMinDMSO , 5108-96-3

Synonym(s):
PDC;APDC;PDTC;Pyrrolidine-1-dithiocarboxylic acid ammonium salt;1-Pyrrolidinecarbodithioic acid ammonium salt

CAS NO.：5108-96-3

Empirical Formula: C5H9NS2.H3N

Molecular Weight: 164.3

MDL number: MFCD00012720

EINECS: 225-834-4

PRODUCT Properties

• Melting point: 153-155 °C(lit.)
• Density: 1.117 (estimate)
• refractive index: 1.5300 (estimate)
• storage temp.: Store at +2°C to +8°C.
• solubility: 190g/l
• form: Powder/Solid
• color: White to off-white
• PH: 6-7 (50g/l, H2O, 20℃)
• Water Solubility: 50 g/L (20 ºC)
• Sensitive: Hygroscopic
• BRN: 3730472
• Stability: Stable. Incompatible with strong oxidizing agents.
• CAS DataBase Reference: 5108-96-3(CAS DataBase Reference)
• EPA Substance Registry System: 1-Pyrrolidinecarbodithioic acid, ammonium salt (5108-96-3)

Description and Uses

Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-κB activation in vitro (100 μM). At 300 μM, it prevents TNF-α gene expression and protein production in human monocytes after LPS application. In vascular smooth muscle cells, PDTC (10 μM) arrests the cell cycle at the G₁ phase with upregulation of p21^Cip1 through the p38 MAPK pathway. PDTC (100 μM) also has antioxidant properties.

Ammonium pyrrolidinedithiocarbamate has been used:

• to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
• to reduce neutrophil activity in rats
• to prevent Ca²⁺ influx in adriamycin (ADR)-treated podocytes

to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi,Xn
• Risk Statements: 36/37/38-22
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• F: 3
• TSCA: Yes
• HS Code: 29339990