Atosiban , 10mMinWater , 90779-69-4
Synonym(s):
1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin;1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin;Tractocile
CAS NO.：90779-69-4
Empirical Formula: C43H67N11O12S2
Molecular Weight: 994.19
MDL number: MFCD00672436
EINECS: 806-815-5
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >165oC (dec.) |
| Boiling point: | 1469.0±65.0 °C(Predicted) |
| Density | 1.254±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | H2O: ≤100 mg/mL |
| form | solid |
| pka | 12.81±0.70(Predicted) |
| color | White to Off-White |
| Water Solubility | Soluble to 50 mg/ml in water |
| CAS DataBase Reference | 90779-69-4(CAS DataBase Reference) |
Description and Uses
Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of the vasopressin V1a receptor and of the oxytocin receptor which is found in dramatically increased concentration in the uterine myometrium of pregnant women near term. It competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with atosiban caused pregnancy prolongation for up to 7 days in women with more than 28 weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic action (uterine relaxant) to ritodrine but the former was significantly better tolerated, especially with regards to maternal cardiovascular side effects. In healthy volunteers, plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.
Premature labor
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P261-P280 |
| WGK Germany | 3 |
| RTECS | RS7590000 |
| HS Code | 2934999090 |
