A7067658
Difluprednate , 10mMinDMSO , 23674-86-4
Synonym(s):
Difluprednate
CAS NO.：23674-86-4
Empirical Formula: C27H34F2O7
Molecular Weight: 508.55
MDL number: MFCD00214273
EINECS: 245-815-4
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB239.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 191-194° |
| alpha | D22 +31.7° (c = 0.5 in dioxane) |
| Boiling point: | 600.3±55.0 °C(Predicted) |
| Density | 1.1869 (estimate) |
| storage temp. | 2-8°C |
| solubility | Dioxane (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 12.56±0.70(Predicted) |
| color | White |
Description and Uses
Difluprednate is a synthetic glucocorticoid that potently activates the glucocorticoid receptor (Ki = 78 pM). In vivo, ocular administration of difluprednate (0.05% w/v) increases intraocular pressure in sheep. Formulations containing difluprednate have been used to treat diabetic macular edema and inflammation following cataract surgery.
Difluprednate-d3 is the isotope labeled form of Difluprednate (D445925), a corticosteroid (derivative of prednisolone), approved for the treatment of post-operative ocular inflammation.
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P501-P202-P201-P280-P308+P313-P405 |
| WGK Germany | 2 |
| RTECS | TU3831500 |
| HS Code | 2937.29.9095 |
| Toxicity | mouse,LD50,intraperitoneal,146mg/kg (146mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: FOOD INTAKE (ANIMAL),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 1066, 1984. |
