2-Acetylphenothiazine , 10mMinDMSO , 6631-94-3
Synonym(s):
NADPH Oxidase-1 Inhibitor, ML171, 2-APT, 2-acetylphenothiazine;NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem
CAS NO.：6631-94-3
Empirical Formula: C14H11NOS
Molecular Weight: 241.31
MDL number: MFCD00005017
EINECS: 229-626-4
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 180-185 °C (lit.) |
| Boiling point: | 455.7±34.0 °C(Predicted) |
| Density | 1.249±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | -2.45±0.20(Predicted) |
| form | Dark yellow-orange powder |
| color | Yellow to Dark Orange |
| λmax | 244nm(MeOH)(lit.) |
Description and Uses
2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 μM. It does not affect xanthine oxidase-dependent or mitochondrial ROS generation. 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells. It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation. 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1. 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 μM.
2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.
