Home Categories Chemical Reagents Diphenyleneiodoniumchloride
A7065958

Diphenyleneiodoniumchloride , 10mMinDMSO , 4673-26-1

Synonym(s):
Dibenziodolium chloride;DPI

CAS NO.:4673-26-1

Empirical Formula: C12H8ClI

Molecular Weight: 314.55

MDL number: MFCD00214165

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: 312-322 °C
storage temp.  room temp
solubility  Soluble in DMSO (up to 5 mg/ml with warming)
form  Powder
color  Off-white
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Description and Uses

Diphenyleneiodonium (DPI) is an inhibitor of NADPH oxidase (NOX; EC50 = 0.1 μM in HeLa cells). It also inhibits nitric oxide synthase (NOS; IC50 = 0.05 μM in isolated mouse peritoneal macrophages). DPI (10, 50, and 100 μM) induces the production of reactive oxygen species (ROS) in, and apoptosis of, human umbilical vein endothelial cells (HUVECs). It inhibits NETosis induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils when used at a concentration of 10 μM. DPI (2 mg/kg) reduces tumor growth in HT-29 and LS 174T colon cancer mouse xenograft models.

Diphenyleneiodonium Chloride binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase.Diphenyleneiodonium Chloride solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  3
HS Code  29310099

RELATED PRODUCTS