Home Categories Biochemical Engineering DorzolamideHCl
A7063658

DorzolamideHCl , 10mMinWater , 130693-82-2

Synonym(s):
Dorzolamide hydrochloride

CAS NO.:130693-82-2

Empirical Formula: C10H17ClN2O4S3

Molecular Weight: 360.9

MDL number: MFCD00884659

EINECS: 620-304-2

Pack Size Price Stock Quantity
1ml RMB239.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 265-2670C
alpha  D24 -8.34° (c = 1 in methanol)
storage temp.  Keep in dark place,Inert atmosphere,2-8°C
solubility  Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol.
form  Solid
color  White to Off-White
λmax 254nm(CHCl3:MeOH= aq.)(lit.)
Merck  14,3426
BRN  5896026
CAS DataBase Reference 130693-82-2(CAS DataBase Reference)

Description and Uses

Dorzolamide hydrochloride was introduced in the U.S.A. as eye drops for the treatment of open-angle glaucoma and ocular hypertension. Dorzolamide is a potent carbonic anhydrase inhibitor that, on topical administration, lowers intraocular pressure (IOP). In a clinical study in patients with bilateral primary open-angle glaucoma or ocular hypertension, dorzolamide (0.7-2%) was found to significantly lower IOP throughout the day. Dorzolamide has been shown to be effective as a single therapy or in combination with β-blockers.

An inhibitor of carbonic anhydrase.

Safety

Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H373
Precautionary statements  P260-P264-P270-P301+P312-P314-P501
WGK Germany  3
RTECS  XJ9095163
HS Code  2935904000

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